Vincent Krenn, in cooperation among others with Dr. Andrej Trampuz and Dr. Nora Renz, has made an interesting research work on CD15 focus score validation for the infection pathology of periprosthetic joint infection in a large group.
The CD15 focus score is a valid, histopathological quantification system for the detection of neutrophilic granulocytes (NG) in periprosthetic tissues. Therefore it allows an efficient, automated (CD 15 quantifier software) and reliable stratification into low- and high-virulence microorganisms. A cut-off value of 106 NG per high power field (HPF) is defined as the optimum threshold for the differentiation between high- and low-virulence microbial pathogens and a cut-off value of 39 NG per HPF marks the distinction between a low-virulence microbial pathogen and no microbial infections.
See the publication here.