PRO-IMPLANT Foundation supports young medical scientists
PRO-IMPLANT Foundation is happy to announce its contribution to the study development of young medical scientists.
1) Prospective analysis of characteristics and treatment outcome of infections after intracranial interventions such as craniotomy/craniectomy, cranioplasty and burr hole trepanations
2) Prospective analysis of characteristics and treatment outcome of cardiovascular implantable electronic devices
1) Retrospective analysis of the influence of an optimized antimicrobial therapy after periprosthetic joint infections
2) Retrospective analysis of the Treatment and outcome of patients with vertebral osteomyelitis
3) Retrospective analysis of the influence of an optimized antimicrobial therapy after implant associated infections of the spine
4) Retrospective analysis of septhic arthritis
1) Retrospective analysis of streptococcal periprosthetic infections with and without rifampicin therapy.
2) Prospective analysis of functional and infectious outcome of all periprothetic hip and knee joint infections treated with two-stage exchange according to an established algorithm between 2013 and 2015.
3) Retrospective comparison of short (<6weeks) vs long (>6weeks) interval in two-stage exchange.
4) Retrospective comparison of difficult-to-treat microorganisms and other organisms treated according to an established algorithm.
1) Development of a new joint aspiration puncture kit. This kit was introduced in both the Mitte and Virchow-campuses of the Charité University clinic. The puncture kit was a clinic-wide success, as it facilitates an easy and standardized joint aspiration and has been since then adopted by several other clinics in Germany and Europe. Since 2015 a biobank with more than 500 samples of periprosthetic joint aspirate and native joint aspirate has been acquired.
2) Rapid Pre-Operative Diagnosis Of Periprosthetic Joint Infection With Microcalorimetry Of Joint Aspirates.
3) Diagnosis Of Periprosthetic Joint Infection By A Novel Multiplex PCR Of Joint Aspirate.
4) The role of microcalorimetry and PCR of joint aspirate for early diagnosis of septic arthritis.
Dr. Stasa Mudrovcic, visiting young physician from Ljubljana, Slovenia is currently performing a 1-month research fellowship at Charité - University Medicine Berlin under the supervision of Dr. Andrej Trampuz.
The role of Propionibacterium causing implant-associated infections is underestimated. Better diagnostic methods and longer prosthesis indwelling time increase the isolation frequency of this pathogen. The aim of Dr. Mudrovcic´s research project is the investigation of the epidemiology, diagnosis, clinical characteristics, treatment and outcome of implant infection caused by Propionibacterium spp.
1. Investigation of bacterial load to different hip and knee prosthetic components by sonication.
2. Evaluation of multiplex PCR for microbiological diagnosis from periprosthetic tissue, sonication and synovial fluid compared to conventional cultures and histopathology.
3. Studying the value of a pathogen-specific marker, D-lactate, for early and accurate diagnosis of septic native joint arthritis and periprosthetic joint infection.
Mouth flora – especially streptococci – is a common cause of periprosthetic joint infection after dental procedures or dental hygiene manipulations. This topic has a high clinical relevance since many periprosthetic joint infection may potentially be prevented by appropriate antibiotic prophylaxis. Current guidelines are not recommending such an antibiotic prophylaxis before dental procedures.
Topic of his research project will be: Infections in orthopedic and trauma surgery.
Ms. Ann Brit-Klatt will perform her master study research project on evaluation in vitro the quantitative activity of a lytic bacteriophage against Streptococcus spp. and E. coli standard and clinical strains, in planktonic and biofilm, using an ultra-sensitive microcalorimeter.
This research brings together authentic, yet unexplored results in the field of biofilms and infectious disease, as well as an unconventional solution as alternative to antibiotics and their resistance and toxicity problems.
Dr. Tamta Tkhilaishvili from Tbilisi, Georgia, will be running her PhD project "Can bacteriophages eradicate microbial biofilms" at Charité-University Medicine Berlin from december 2015 till June 2017.
Biofilm microorganisms are up to 1,000 times more resistant to antibiotics than their planktonic (free-living) counterparts. The increasing development of antibiotic resistance problems lead to the investigation of new ways to fight biofilm infections, such as the use of bacteriophages.
This innovative project may lead to new treatment concepts for difficult-to treat infections, for which there are no antibiotics available at the moment.
Mrs. Magdalena Czuban from Poland is currently running her PhD project "Development of a new catch & release antibiotic delivery system (“click chemistry”) for local treatment of bone and implant infections" at the Charité-University Medicine Berlin.
The hypothesis of this project is that antibiotics can be concentrated through bioorthogonal chemistry at an implanted biomaterial and then released through a cascade reaction.
Ms. Mercedes Gonzalez Moreno from Spain is currently running her PhD project "The undiscovered properties of fosfomycin: Activity against streptococcal biofilms" under the supervision of Dr. Andrej Trampuz.
The goal of this project is to evaluate the activity of an “old” antibiotic, fosfomycin, against streptococci, alone and in combination with rifampin, daptomycin and gentamicin in vitro and in the experimental model. This project may open new treatment possibilities for intra- end extravascular implant-associated infections.
Ms. Ines da Fonseca Santos Ferreira, PhD from Lisbon, Portugal, was running her PhD project “Study to determine the antibiofilm effect of antibiotic loaded cerament™ │G” at Charité-University Medicine Berlin from August 1, 2014 till April 30, 2015.
One of the main aims of PRO-IMPLANT Foundation is to highlight the role of biofilms in prosthetic joint infections and contribute the research in the field. Therefore PIF had the honor to support Mrs. Ferreira with scholarship in her project.
PRO-IMPLANT Foundation is committed to support innovative researches in the field of prosthetic joint infections also in the future.